Regulators of T Cell activation and function

We are interested in the mechanisms controlling T cell activation and effector functions in asthma, pulmonary infections and lung transplantation. Specifically, we use mouse models of disease, genetically modified mice, cellular immunology techniques, and translational human studies to characterize the role of effector and regulatory T cells in health and disease. We have demonstrated the importance of CARMA1 in the development of allergic airway inflammation and regulatory T cell development, the role of Tim3 in modulating the response to influenza infection and transplant rejection, and the role of Mst1 in T cell development and activation.