News
See no allergen, hear no allergen, speak no allergen! May 5, 2023
Five Questions with Jehan Alladina, Apr 1, 2022
New target identified for treatment of pulmonary fibrosis, Rachel S. Knipe, MD, Benjamin D. Medoff, MD, Advances in Motion, March 28, 2022
Discovering the pathways that lead to allergic asthma, Jehan A. Alladina MD, Advances in Motion, February 8, 2022
Endothelial signaling pathway linked to pulmonary fibrosis, Rachel S. Knipe, MD, Advances in Motion, January 26, 2022
Full List of Publications
Recent Publications
Alladina J, Smith NP, Kooistra T, Slowikowski K, Kernin IJ, Deguine J, Keen HL, Manakongtreecheep K, Tantivit J, Rahimi RA, Sheng SL, Nguyen ND, Haring AM, Giacona FL, Hariri LP, Xavier RJ, Luster AD, Villani AC, Cho JL, Medoff BD. A human model of asthma exacerbation reveals transcriptional programs and cell circuits specific to allergic asthma. Sci Immunol. 2023 May 12;8(83):eabq6352. doi: 10.1126/sciimmunol.abq6352. Epub 2023 May 5. PMID: 37146132.
Knipe RS, Nurunnabi M, Probst CK, Spinney JJ, Abe E, Bose RJC, Ha K, Logue A, Nguyen T, Servis R, Drummond M, Haring A, Brazee PL, Medoff BD, McCarthy JR. Myofibroblast-specific inhibition of the Rho kinase-MRTF-SRF pathway using nanotechnology for the prevention of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2023 Feb 1;324(2):L190-L198. doi: 10.1152/ajplung.00086.2022. Epub 2023 Jan 10. PubMed PMID: 36625494; PubMed Central PMCID: PMC9925159.
Yang Y, Santos DM, Pantano L, Knipe R, Abe E, Logue A, Pronzati G, Black KE, Spinney JJ, Giacona F, Bieler M, Godbout C, Nicklin P, Wyatt D, Tager AM, Seither P, Herrmann FE, Medoff BD. Screening for Inhibitors of YAP Nuclear Localization Identifies Aurora Kinase A as a Modulator of Lung Fibrosis. Am J Respir Cell Mol Biol. 2022 Apr 4. doi: 10.1165/rcmb.2021-0428OC. Epub ahead of print. PMID: 35377835.
Knipe RS, Spinney JJ, Abe EA, Probst CK, Franklin A, Logue A, Giacona F, Drummond M, Griffith J, Brazee PL, Hariri LP, Montesi SB, Black KE, Hla T, Kuo A, Cartier A, Engelbrecht E, Christoffersen C, Shea BS, Tager AM, Medoff BD. Endothelial-Specific Loss of Sphingosine-1-Phosphate Receptor 1 Increases Vascular Permeability and Exacerbates Bleomycin-induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2022 Jan;66(1):38-52. doi: 10.1165/rcmb.2020-0408OC. PubMed PMID: 34343038; PubMed Central PMCID: PMC8803357.
Nandy S, Raphaely RA, Muniappan A, Shih A, Roop BW, Sharma A, Keyes CM, Colby TV, Auchincloss HG, Gaissert HA, Lanuti M, Morse CR, Ott HC, Wain JC, Wright CD, Garcia-Moliner ML, Smith ML, VanderLaan PA, Berigei SR, Mino-Kenudson M, Horick NK, Liang LL, Davies DL, Szabari MV, Caravan P, Medoff BD, Tager AM, Suter MJ, Hariri LP. Diagnostic Accuracy of Endobronchial Optical Coherence Tomography for the Microscopic Diagnosis of Usual Interstitial Pneumonia. Am J Respir Crit Care Med. 2021 Nov 15;204(10):1164-1179. doi: 10.1164/rccm.202104-0847OC. PubMed PMID: 34375171; PubMed Central PMCID: PMC8759308.
Corleis B, Cho JL, Gates SJ, Linder AH, Dickey A, Lisanti-Park AC, Schiff AE, Ghebremichael M, Kohli P, Winkler T, Harris RS, Medoff BD, Kwon DS. Smoking and Human Immunodeficiency Virus 1 Infection Promote Retention of CD8+ T Cells in the Airway Mucosa. Am J Respir Cell Mol Biol. 2021 Nov;65(5):513-520. doi: 10.1165/rcmb.2021-0168OC. PubMed PMID: 34166603; PubMed Central PMCID: PMC8641855.
Zubiri L, Molina GE, Mooradian MJ, Cohen J, Durbin SM, Petrillo L, Boland GM, Juric D, Dougan M, Thomas MF, Faje AT, Rengarajan M, Guidon AC, Chen ST, Okin D, Medoff BD, Nasrallah M, Kohler MJ, Schoenfeld SR, Karp-Leaf RS, Sise ME, Neilan TG, Zlotoff DA, Farmer JR, Bardia A, Sullivan RJ, Blum SM, Semenov YR, Villani AC, Reynolds KL. Effect of a multidisciplinary Severe Immunotherapy Complications Service on outcomes for patients receiving immune checkpoint inhibitor therapy for cancer. J Immunother Cancer. 2021 Sep;9(9). doi: 10.1136/jitc-2021-002886. PubMed PMID: 34544895; PubMed Central PMCID: PMC8454442.
Alba GA, Ziehr DR, Rouvina JN, Hariri LP, Knipe RS, Medoff BD, Hibbert KA, Kowal A, Hoenstine C, Ginns LC, Lewis GD, Hardin CC. Exercise performance in patients with post-acute sequelae of SARS-CoV-2 infection compared to patients with unexplained dyspnea. EClinicalMedicine. 2021 Sep;39:101066. doi: 10.1016/j.eclinm.2021.101066. eCollection 2021 Sep. PubMed PMID: 34476393; PubMed Central PMCID: PMC8401400.
Gard AL, Luu RJ, Miller CR, Maloney R, Cain BP, Marr EE, Burns DM, Gaibler R, Mulhern TJ, Wong CA, Alladina J, Coppeta JR, Liu P, Wang JP, Azizgolshani H, Fezzie RF, Balestrini JL, Isenberg BC, Medoff BD, Finberg RW, Borenstein JT. High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitro. Sci Rep. 2021 Jul 22;11(1):14961. doi: 10.1038/s41598-021-94095-7. PubMed PMID: 34294757; PubMed Central PMCID: PMC8298517.
McNeill JN, Lau ES, Zern EK, Nayor M, Malhotra R, Liu EE, Bhat RR, Brooks LC, Farrell R, Sbarbaro JA, Schoenike MW, Medoff BD, Lewis GD, Ho JE. Association of obesity-related inflammatory pathways with lung function and exercise capacity. Respir Med. 2021 Jul;183:106434. doi: 10.1016/j.rmed.2021.106434. Epub 2021 Apr 30. PubMed PMID: 33964816; PubMed Central PMCID: PMC8144063.
Alladina JW, Giacona FL, White EB, Brait KL, Abe EA, Michelhaugh SA, Hibbert KA, Januzzi JL, Thompson BT, Cho JL, Medoff BD. Soluble Suppression of Tumorigenicity-2 Associates With Ventilator Dependence in Coronavirus Disease 2019 Respiratory Failure. Crit Care Explor. 2021 Jul;3(7):e0480. doi: 10.1097/CCE.0000000000000480. eCollection 2021 Jul. PubMed PMID: 34235459; PubMed Central PMCID: PMC8245109.
Molina GE, Zubiri L, Cohen JV, Durbin SM, Petrillo L, Allen IM, Murciano-Goroff YR, Dougan M, Thomas MF, Faje AT, Rengarajan M, Guidon AC, Chen ST, Okin D, Medoff BD, Nasrallah M, Kohler MJ, Schoenfeld SR, Karp Leaf RS, Sise ME, Neilan TG, Zlotoff DA, Farmer JR, Mooradian MJ, Bardia A, Mai M, Sullivan RJ, Semenov YR, Villani AC, Reynolds KL. Temporal Trends and Outcomes Among Patients Admitted for Immune-Related Adverse Events: A Single-Center Retrospective Cohort Study from 2011 to 2018. Oncologist. 2021 Jun;26(6):514-522. doi: 10.1002/onco.13740. Epub 2021 Mar 31. PubMed PMID: 33655682; PubMed Central PMCID: PMC8176966.
Alladina J, Levy SD, Cho JL, Brait KL, Rao SR, Camacho A, Hibbert KA, Harris RS, Medoff BD, Januzzi JL, Thompson BT, Bajwa EK. Plasma Soluble Suppression of Tumorigenicity-2 Associates with Ventilator Liberation in Acute Hypoxemic Respiratory Failure. Am J Respir Crit Care Med. 2021 May 15;203(10):1257-1265. doi: 10.1164/rccm.202005-1951OC. PubMed PMID: 33400890; PubMed Central PMCID: PMC8456472.
Kohli P, Kelly VJ, Hibbert KA, Corleis B, Kone M, Cho JL, DeFaria-Yeh D, Kwon DS, Medoff BD, Harris RS, Winkler T. PET Imaging Reveals Early Pulmonary Perfusion Abnormalities in HIV Infection Similar to Smoking. J Nucl Med. 2021 Mar;62(3):405-411. doi: 10.2967/jnumed.120.245977. Epub 2020 Aug 6. PubMed PMID: 32764123; PubMed Central PMCID: PMC8049351.
Schiff AE, Linder AH, Luhembo SN, Banning S, Deymier MJ, Diefenbach TJ, Dickey AK, Tsibris AM, Balazs AB, Cho JL, Medoff BD, Walzl G, Wilkinson RJ, Burgers WA, Corleis B, Kwon DS. T cell-tropic HIV efficiently infects alveolar macrophages through contact with infected CD4+ T cells. Sci Rep. 2021 Feb 16;11(1):3890. doi: 10.1038/s41598-021-82066-x. PubMed PMID: 33594125; PubMed Central PMCID: PMC7886866.
Schwartzstein RM, Medoff BD, Sharma A, Colson YL, Gainor J, Hariri LP. Case 4-2021: A 70-Year-Old Woman with Dyspnea on Exertion and Abnormal Findings on Chest Imaging. N Engl J Med. 2021 Feb 11;384(6):563-574. doi: 10.1056/NEJMcpc2027088. PubMed PMID: 33567196.
Hariri LP, North CM, Shih AR, Israel RA, Maley JH, Villalba JA, Vinarsky V, Rubin J, Okin DA, Sclafani A, Alladina JW, Griffith JW, Gillette MA, Raz Y, Richards CJ, Wong AK, Ly A, Hung YP, Chivukula RR, Petri CR, Calhoun TF, Brenner LN, Hibbert KA, Medoff BD, Hardin CC, Stone JR, Mino-Kenudson M. Lung Histopathology in Coronavirus Disease 2019 as Compared With Severe Acute Respiratory Sydrome and H1N1 Influenza: A Systematic Review. Chest. 2021 Jan;159(1):73-84. doi: 10.1016/j.chest.2020.09.259. Epub 2020 Oct 7. PubMed PMID: 33038391; PubMed Central PMCID: PMC7538870.
Ziehr DR, Alladina J, Petri CR, Maley JH, Moskowitz A, Medoff BD, Hibbert KA, Thompson BT, Hardin CC. Reply to Yaroshetskiy et al.: Acute Respiratory Distress Syndrome in COVID-19: Do All These Patients Definitely Require Intubation and Mechanical Ventilation?. Am J Respir Crit Care Med. 2020 Nov 15;202(10):1481-1482. doi: 10.1164/rccm.202007-2972LE. PubMed PMID: 32809839; PubMed Central PMCID: PMC7667895.
Faustino LD, Griffith JW, Rahimi RA, Nepal K, Hamilos DL, Cho JL, Medoff BD, Moon JJ, Vignali DAA, Luster AD. Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung. Nat Immunol. 2020 Nov;21(11):1371-1383. doi: 10.1038/s41590-020-0785-3. Epub 2020 Sep 28. PubMed PMID: 32989331; PubMed Central PMCID: PMC7578082.
Ziehr DR, Alladina J, Petri CR, Maley JH, Moskowitz A, Medoff BD, Hibbert KA, Thompson BT, Hardin CC. Reply to Epelbaum: Standards and Stereotypes in COVID-19. Am J Respir Crit Care Med. 2020 Aug 1;202(3):470-471. doi: 10.1164/rccm.202005-1944LE. PubMed PMID: 32510977; PubMed Central PMCID: PMC7397799.
Probst CK, Montesi SB, Medoff BD, Shea BS, Knipe RS. Vascular permeability in the fibrotic lung. Eur Respir J. 2020 Jul 16;56(1):1900100. doi: 10.1183/13993003.00100-2019. PMID: 32265308.
Ziehr DR, Alladina J, Petri CR, Maley JH, Moskowitz A, Medoff BD, Hibbert KA, Thompson BT, Hardin CC. Respiratory Pathophysiology of Mechanically Ventilated Patients with COVID-19: A Cohort Study. Am J Respir Crit Care Med. 2020 Jun 15;201(12):1560-1564. doi: 10.1164/rccm.202004-1163LE. PMID: 32348678; PMCID: PMC7301734.
Santos DM, Pantano L, Pronzati G, Grasberger P, Probst CK, Black KE, Spinney JJ, Hariri LP, Nichols R, Lin Y, Bieler M, Seither P, Nicklin P, Wyatt D, Tager AM, Medoff BD. Screening for YAP Inhibitors Identifies Statins as Modulators of Fibrosis. Am J Respir Cell Mol Biol. 2020 Apr;62(4):479-492. doi: 10.1165/rcmb.2019-0296OC. PMID: 31944822; PMCID: PMC7110981.
Di Pilato M, Kim EY, Cadilha BL, Prüßmann JN, Nasrallah MN, Seruggia D, Usmani SM, Misale S, Zappulli V, Carrizosa E, Mani V, Ligorio M, Warner RD, Medoff BD, Marangoni F, Villani AC, Mempel TR. Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy. Nature. 2019 Jun;570(7759):112-116. doi: 10.1038/s41586-019-1215-2. Epub 2019 May 15. PMID: 31092922; PMCID: PMC6656391.
Adams DC, Miller AJ, Applegate MB, Cho JL, Hamilos DL, Chee A, Holz JA, Szabari MV, Hariri LP, Harris RS, Griffith JW, Luster AD, Medoff BD, Suter MJ. Quantitative assessment of airway remodelling and response to allergen in asthma. Respirology. 2019 Nov;24(11):1073-1080. doi: 10.1111/resp.13521. Epub 2019 Mar 7. PMID: 30845351; PMCID: PMC6732047.
Corleis B, Bucsan AN, Deruaz M, Vrbanac VD, Lisanti-Park AC, Gates SJ, Linder AH, Paer JM, Olson GS, Bowman BA, Schiff AE, Medoff BD, Tager AM, Luster AD, Khader SA, Kaushal D, Kwon DS. HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis. Cell Rep. 2019 Feb 5;26(6):1409-1418.e5. doi: 10.1016/j.celrep.2019.01.021. PMID: 30726727; PMCID: PMC6417097.
Causton B, Pardo-Saganta A, Gillis J, Discipio K, Kooistra T, Rajagopal J, Xavier RJ, Cho JL, Medoff BD. CARMA3 Mediates Allergic Lung Inflammation in Response to Alternaria alternata. Am J Respir Cell Mol Biol. 2018 Dec;59(6):684-694. doi: 10.1165/rcmb.2017-0181OC. PMID: 29958012; PMCID: PMC6293075.
Cho JL, Medoff BD. Chronic Obstructive Pulmonary Disease: Back to the Basics. Am J Respir Crit Care Med. 2018 Nov 15;198(10):1241-1242. doi: 10.1164/rccm.201806-1148ED. PMID: 30011221.