The Medoff Laboratory studies the mechanisms of lung injury, inflammation and fibrosis in the pathophysiology of several important pulmonary diseases, including asthma, idiopathic pulmonary fibrosis, lung transplant rejection, chronic obstructive pulmonary disease, and respiratory viral infections such as influenza. Using animal models of disease, cutting edge molecular biology techniques, integrative genomics, and translational studies in humans, the Medoff Laboratory investigates the molecular mechanisms involved in the development of lung inflammation and fibrosis in order to reveal novel aspects of lung biology and immunity, and to identify potential therapeutic targets for these disorders.

The laboratory is affiliated with the Division of Pulmonary and Critical Care Medicine in the Department of Medicine at MGH, as well as the Center for Immunology and Inflammatory Diseases, the Andrew M. Tager Fibrosis Center, and the Division of Rheumatology, Allergy, and Immunology.